Scientific Programme

as of 8 December 2014


International Mast Cell and Basophil Meeting 2014

Scientific Programme Committee

T. Biedermann, S. Bischoff, U. Blank, F. Falcone, M. Köberle, M. Maurer, G. Nilsson, C. Sommerhoff

Local Organizing Committee

T. Biedermann, K. Brockow, M. Köberle

11-12 December 2014, Munich/Germany



Book of Abstracts

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Wednesday, 10 December 2014

13:00 - 14:00Lunch

14:00 - 16:00

Retreat of SPP1394 Mast Cells - Promoters of Health and Modulators of Disease

16:00 - 16:30

Coffee Break

16:30 - 17:30    

EMBRN Executive Meeting

18:00 - 19:00                              

COST Meeting

WG1 - 4




Thursday, 11 December 2014

Welcome Ceremony

09:00 - 09:30

Session I

09:30 - 10:30

Mast cell and basophil interaction with other cells.

Chairs: S. Bischoff / F. Levi-Schaffer


Nerve-mast cell interaction in the human intestine. Sabine Bühner (Freising)

09:38 The role of mast cells as mediators of tissue injury and systemic inflammation in cardiac surgery. Jörn Karhausen (Durham)
09:46 Bidirectional counter-regulation of human lung mast cell and airway smooth muscle β2-adrenoceptors. Peter Bradding (Leicester)
09:54 Human mast cells engulf and store exogenous IL-17A. Troy Noordenbos (Amsterdam)
10:02 IL-10 and IFNs regulate the IL-3-mediated effector functions of human basophils. Björn Hagmann (Bern)
10:10 Mast cells control the expansion and differentiation of IL-10-competent B cells. Francesca Mion (Udine)
10:18 Crosstalk between allergy, inflammation and leukaemia: Hypoxic signalling mechanisms control IL-1 βR -induced SCF production by epithelial cells. Bernhard Gibbs (Chatham Maritime)



Coffee Break (10:30 - 11:00)


Keynote lecture I

11:00 - 12:00

Is there a hyperreactive mast cell phenotype?

Dean Metcalfe

Introduction: K. Brockow

Session II

12:00 - 13:05

Mast cell and basophil activation and mediators

Chairs: D. Metcalfe / U. Blank

12:00 Mast cells determine the adaptive immune response in contact hypersensitivity. Anne Dudeck (Dresden)
12:08 Mast cells and Mcpt4 chymase promote renal impairment after partial ureteral obstruction. Maguelonne Pons (Paris)
12:16 Increased capsaicin-induced bronchoconstriction in cause of passive sensitization of human precision-cut lung slices is NK1 receptor, histamine 1 receptor and IgE dependent. Susann Schindler, Sharon Jiménez Delgado (Hannover)
12:24 Generation and characterization of antibodies directed against human mast cell tryptases. Maresa Grundhuber (Munich)
12:32 Mast cells limit the level of inflammation and mast cell chymase (mMCP-4) regulates the interleukin-33 level in MC903-induced atopic dermatitis. Sofie Svanberg (Uppsala)
12:40 IkappaB kinase 2 controls the allergen-induced mast cell cytokine response but is dispensable for mast cell degranulation. Axel Roers (Dresden)
12:48 FGD2 is a novel negative regulator of IgE-dependent mast cell activation. Graham Mackay (Parkville)



Lunch (13:05 - 14:00)


Session III

14:00 - 15:00

Mast cells and basophils in shaping the inflammatory tumor infiltrate

Chairs: F. Falcone / C. Pucillo

14:00 A role for tumor-specific IgE in tumor defense. Susanne Kaesler (Tübingen)
14:08 Mast cells - prostate cancer stem cells crosstalk protects against neuroendocrine tumor development. Elena Jachetti (Milan)
14:16 Mast cells are increased in human lung adenocarcinoma and promote growth of murine lung cancer. Karin Hartmann (Cologne)
14:24 Mast cell-derived exosomes as mediators of antitumor activity. Frederica D'Incŕ (Udine)
14:32 Immunoglobulin E plays an immuno-regulatory role in lupus. Barbara Dema (Paris)
14:40 Cell-cell contact and autocrine adenosine signaling mediate the direct activation of mast cells by cancer cells. Ronit Sagi-Eisenberg (Tel Aviv)
14:48 Non-human primates reflect anatomical features and functions of mast cell-C-fibers. Sharon Jiménez Delgado, Susann Schindler (Hannover)

Keynote lecture II

15:00 - 16:00

The role of mast cells in IL-17 associated autoimmune inflammation

Melissa Brown

Introduction: M. Maurer

Poster Viewing

16:00 - 17:00

Odd numbers

With drinks and snacks

Session IV

17:00 - 18:05

Mast cell and basophil biology

Chairs: G. Nilsson / M. Brown

17:00 Molecular editing of cellular responses by the high affinity receptor for IgE. Ryo Suzuki (Bethesda)
17:08 Distinguishing mast cell progenitors from mature mast cells in mice. Joakim Dahlin (Uppsala)
17:16 Uterine mast cells and uterine natural killer cells are both required for optimal spiral artery remodeling and fetal growth. Nicole Meyer (Magdeburg)
17:24 Myo1f links 3BP2 to actin remodeling in mast cells. Arnau Navinés-Ferrer (Barcelona)
17:32 Functional expression of aryl hydrocarbon receptor on mast cells populating human endometriotic tissues. Giorgia Gri (Udine)
17:40 Proteome analysis of human primary skin derived mast cells. Maria Gschwandtner (Vienna)
17:48 New roles of Galectin-3 in FceRI signaling. Monika Bambouskova (Prague)
18:56 The circadian clock controls IgE-dependent activation of human mast cells. Anja Baumann (Stuttgart)


EMBRN General Assembly

18:00 - 19:00



Dinner and discussion

19:30 - open end



Friday, 12 December 2014

Session V

08:30 - 09:30

Mast cells and basophils in infection

Chairs: F. Redegeld / M. Köberle

08:30The IL-33/ST2 axis on mast cells contributes to protective immune responses to herpes simplex virus-2. Rui Aoki (Yamanashi)
08:38Mucosal but not connective tissue mast cells are required for final termination of Strongyloides ratti. Martina Reitz (Hamburg)
08:46Mast cells control skin wound infection with Pseudomonas aeruginosa. Carolin Sieber (Berlin)
08:54Mast cells induce a specific response against opportunistic pathogenic Candida albicans. Pedro Lopes (Umeĺ)
09:02Genetic background determines outcome of infections with Leishmania major in mast cell-deficient mice. Kirsten Dietze-Schwonberg (Mainz)
09:10Mast cells exert control of pulmonary murine cytomegalovirus infection. Michael Stassen (Mainz)
09:18Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo. Elin Rönnberg (Uppsala)

Keynote lecture III

09:30 - 10:00

The role of mast cells, basophils, and IgE in urticaria

Markus Maurer

Introduction: T. Biedermann


Coffee break 10:00 - 10:30



10:30 - 11:30

Mast cell and basophil proteases

(kindly supported by Phadia Thermo Fischer)


Introduction on the role of tryptase for diagnostic purposes Tilo Biedermann (Munich)


Human tryptases: structure and function Christian Sommerhoff (Munich)


Biological role of mast cell proteases Gunnar Pejler (Uppsala)


Lunch (11:30 - 12:30)


Poster Viewing


Even numbers

With drinks and snacks

Session VI

13:30 - 14:30

Joint session with EuroBAT

Chairs: B. Gibbs / B. Eberlein

13:30The role of basophils during immune responses against helminths. Christian Schwartz (Erlangen)
13:38Specific TLR activation mediates innate immune signal triggered co-factor dependent anaphylaxis. Florian Wölbing (Tübingen)
13:46Targeting synovial mast cells in spondyloarthritis: A proof of concept study with the tyrosine kinase inhibitor Nilotinib. Troy Noordenbos (Amsterdam)
13:54Basophils modulate T cell responses in models of colitis and graft-versus host disease. Matthias Mack (Regensburg)
14:02Human basophils support plasma cell development and maturation. Dorothea Dijkstra (Hannover)
14:10Phosphatidylserine inhibits anaphylactic IgE/FceRI-dependent basophil activation through the inhibitory receptor CD300a (IRp60). Vito Sabato (Antwerp)
14:18Assessment of mast cell/basophil degranulation by cell surface protein analysis and intracellular histamine. Zane Orinska (Borstel)



COST MC-Meeting


End of the meeting


IMCBM 2014 COST (European Cooperation in Science and Technology) European Mastcell and Basophil Research Network